• Recommended by healthcare professionals in Germany since 1993
• Multiple in vitro and in vivo studies for toxicology and metabolism demonstrate a high degree of predicted safety*^8-12
• No clinically relevant changes in safety parameters—including gynecological findings, vital parameters, and laboratory safety parameters associated with treatment after 108 weeks of clinical observation*²

Unlike hormone therapies, ERr 731 does not contain estrogen

• The observed clinical benefits of ERr 731 appear to be related to modulation of ERβ as demonstrated in laboratory studies*^8-12
• Siberian rhubarb is a vegetable like its relative—garden rhubarb (Rheum rhabarbarium)
• All active constituents of ERr 731 are identified as hydroxystilbenes (phytonutrients), primarily rhaponticin
• ERr 731 does not contain anthraquinones, which are constituents of medicinal rhubarb plants traditionally used to treat occasional constipation and have potential liver toxicity*